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Jim Kling

Louis J. Picker

The Scientist

CD4+

CD4+ Reliability

Column

2001

Research disputes theory that decrease in CD4+ T cells signifies AIDS progression. Findings suggest HIV-specific CD4+ T cell levels aren't accurate disease markers.

This is a summary of an article disputing a theory about the progression of AIDS. The theory suggested that a decrease in CD4+ T cells, which are important for the immune response to HIV, would lead to disease progression. However, the author of the article, Louis J. Picker, argues that this theory is flawed. He conducted experiments and found that patients with low levels of CD4+ T cells still had surviving populations of these cells. He suggests that CD4+ T cell levels are not an accurate marker of disease progression. Picker's work has improved the methodology for studying the immune system. Overall, this article challenges the previous theory and provides new insights into the role of CD4+ T cells in AIDS progression.

AIDS Progression

CD4+ T cells

HIV-1

Disease progression

Viral load

Immune system process

Flow cytometry assay

Louis J. Picker

Vaccine and Gene Therapy Institute

Antiretroviral therapy

HIV-specific CD4+ T cell counts

Oregon Health Sciences University

Keyword of the image