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Abstract
The theory Is advanced that cellular processes have a cyclic nature controlled by a periodic charge exchange between actin and myosin, regulated by the oxidation and reduction of sulphydryl moieties Cellular characteristics and control including mitosis are determined by the redox state of these two proteins; mitosis being determined by both the amplitude and period of the thlol cycle. It Is proposed that all carcinogens induce an oxidation of specific myosin sulphydryl units with a concomitant reduction of specific actin sulphydryl units. They thereby Initiate a thiol cycle of Increased magnitude which leads to mitosis. This theory leads to predictions concerning the manner In which reducing agents and hyperthermia should be used In the prevention and treatment of cancer.
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