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Author

  • Vladimir Koliadin

Publisher

  • -

Category

  • HIV Tests

Topic

  • HIV Test Accuracy

Article Type

  • Editorial Article

Publish Year

  • 1999

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Meta Description

  • Studies show HIV tests' high specificity but don't prove HIV's existence. False positives are rare. Some argue tests' use as diagnostic tools needs review.

Summary

  • The content discusses the issue of HIV-positivity and its relationship to AIDS. It questions the validity of studies that claim HIV-positivity is specific to AIDS, pointing out that the control group in these studies was not properly matched to the AIDS group. The importance of matched control groups in scientific studies is emphasized. The content also highlights the presence of non-specific immunoglobulins in the body and their potential to yield false positive HIV tests. It explains that only a portion of immunoglobulins produced in response to an antigen are specific, while the majority are non-specific. The problem of non-specific immunoglobulins is further exacerbated in certain HIV test systems. The content concludes by stating that the available evidence suggests that HIV antibody tests are not standardized or reproducible, and the proteins considered specific to HIV may actually be normal cellular proteins. It questions the specificity of the Western Blot test and suggests that a positive result may be due to cross-reactivity with non-HIV antibodies.

Meta Tag

  • HIV

  • AIDS

  • HIV-antibodies

  • HIV-seropositivity

  • HIV-tests

  • Specificity

  • Western Blot (WB) test

  • ELISA systems

  • False positive

  • Antigen

  • Immunoglobulins

  • T4-lymphocytopenia

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By Vladimir Koliadin
April 1998 (Revised June 1999)

...

In Russia, it was found occasionally that even relatively small dilution 3-8 times (when samples from 3-8 individuals are pooled together) often lead to negative results of ELISA, when one sample of the several ones was positive (if tested separately - not in the pooled). Technically this means that titers of [antigen-antibody] reaction was quite low - < 1:3 -1:8 - lower than standards of practical immunochemistry require.

References

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